Specific auditory memory induced by nucleus basalis stimulation depends on intrinsic acetylcholine
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چکیده
منابع مشابه
Specific auditory memory induced by nucleus basalis stimulation depends on intrinsic acetylcholine.
Although the cholinergic system has long been implicated in the formation of memory, there had been no direct demonstration that activation of this system can actually induce specific behavioral memory. We have evaluated the "cholinergic-memory" hypothesis by pairing a tone with stimulation of the nucleus basalis (NB), which provides acetylcholine to the cerebral cortex. We found that such pair...
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Hypothesized circuitry enabling behavioral memory formation can be tested by its direct activation in the absence of normal experience. Neuromodulation via the cortical release of acetylcholine by the nucleus basalis (NB) is hypothesized to be sufficient to induce specific, associative behavioral memory. Previously, we found that tone paired with stimulation of the nucleus basalis (NBs) for 300...
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The cholinergic system has been implicated in learning and memory. The nucleus basalis (NB) provides acetylcholine (ACh) to the cerebral cortex. Pairing a tone with NB stimulation (NBstm) to alter cortical state induces both associative specific tuning plasticity in the primary auditory cortex (A1) and associative specific auditory behavioral memory. NB-induced memory has major features of natu...
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ژورنال
عنوان ژورنال: Neurobiology of Learning and Memory
سال: 2008
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2008.05.010